Intended Use
Keypath p16 Immunoassay Test Kit(ICC) is used for immunohistochemical staining on the basis of routine staining
(such asHE staining), and provides diagnostic auxiliary information for doctors.
Principle
Based on the principle of specific binding between immunological antigen and antibody, the antibody is combined with enzyme-labeled chromogenic system to form a complex, and enzyme substrate (chromogenic agent) is added to make it chromogenic to locate and characterize the antigen to be detected. The location of cell staining is nucleus/cytoplasm.
P16 is one of the cell cycle regulatory proteins, also known as "mitosis inhibitor". Its role is to competitively bind CDK4/6 with cyclin D, and stop
the process of cells from G1 to S, thus negatively regulating mitosis. In tumor cells, gene mutation or deletion often leads to the increase of p16
expression, but the cell cycle can not be regulated. This antibody is mainly used in tumor research.
Higher sensitivity
- Bypassed with higher sensitivity and specificity
- Specificity much high than HR-HPV detection
Packaging
- 25 tests/kit ,50 tests/kit ,100 tests/kit
